A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates
Released on J-STAGE: February 28, 2009 |
Volume 24
Issue 1
Pages 53-75
Masoud JAMEI, Gemma L DICKINSON, Amin ROSTAMI-HODJEGAN